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Assoc.Prof. Le Van Tho
Technical adviser of BIO-PHARMACHEMIE cooperation
Porcine Epidemic Diarrhea (P.E.D) is a disease caused by virus and affect the economy due to the high mortality in piglets and rapidly transmit throughout the herd.
Pathogenesis:
PED virus is present in feces, on the floor, skin and hair of sows. Virus invades through oral path, replicates in small intestinal epithelium, damages intestinal vili system, reduces enzyme action on surface of intestine lead to decrease the absorption of nutrients and fluid results in diarrhea, dehydration, lack of energy and death.
Diarrhea caused by bacteria does not occur rapidly in a wide area, it appears slowly on only a few individuals in herd and can be treated by antibiotics.
Meanwhile, P.E.D caused by virus, severe diarrhea occurs rapidly and in all ages, it can spread throughout the herd, included sows. Primary clinical signs are vomiting, yellow watery diarrhea, stink, undigested-milk in feces. Pigs huddle together for warmth due to lack of energy. New-born piglets are the most susceptible with high mortality.
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Treatment:
Immediately supply water/fluid and electrolytes and use medicine to control diarrhea.
· The most effective method to deal with dehydration is fluid therapy (intraperitoneal fluid transfusion) for piglets, Lactate ringer in the morning and BIO-GLUCOSE 5% in the afternoon. Dose is 10-20 ml/ piglet/ time.
· Using BIO-GUARD or BIO-NEW DIARRHEA STOP for piglets to control diarrhea and inject BIO-COLISTIN, BIO-D.O.C ® or BIO-FLORSONE to avoid secondary infection by E.coli or Salmonella.
When the outbreak occurs, disinfect the pens with BIO-GUARD 2 times per day to prevent the disease transmission. This is the new generation of disinfectants, combination of Formaldehyde, Glutaraldehyde and Benzalkonium cloride, safe and effective, rapidly active, last longer, kill all pathogens include bacteria, virus, yeast, spores.
· Keep the pens warm, raise the temperature in piglet pens 2-3°C higher than normal
· When the pigs recover, supply BIO-ZYME PLUS in feed to increase the digestibility and absorbability, create the balance of micro-flora in intestine to prevent the diarrhea recurring.
Prevention:.
- The pathogen is present on the floor and in the feces so proper disinfection of pens and application of biosecurity should be done thoroughly.
- Provide antibodies for new-born piglets as a prevention method.
- Induce artificial infection (or auto-vaccine) for sows by feeding small intestines of 1-week old piglets infected with P.E.D.
- Small intestines after collection are cut into pieces, ground and mixed with normal saline, then stored in refrigerator (2-8oC).
- Mix 1g BIO-AMOX+TYLOSIN with 200 ml normal saline and the mixture of small intestine prepared above.
- Feed sows, replacement gilts and 14-week pregnant sows with 10ml/pig.
- This can be done by using feces from infected piglet dissolved in water and add into sow feed. The sows will generate antibodies and transmit to piglets through colostrum so next litters will not infected by P.E.D.
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